Association of Genetic Factors in the Occurrence of Acne Vulgaris and its Implication in the Development of Severe Acne

Acne is an inflammatory disease that usually affects the pilosebaceous unit. It a very common worldwide and its onset during puberty common. Multiple studies have shown up to 95% of adolescents will be affected some degree their lifetime, being female sex most affected. frequently associated with monogenic diseases such as Apert syndrome; comedonal nevus; Frank-ter Haar syndrome, among others. The pathogenesis multifactorial, however, it has been demonstrated there are four interrelated factors, these increase sebum production, hyperkeratinization follicular infundibulum, inflammation microbial infection. Some genes involved in patients SELL, DBB2 TP53, whose function regulation hemostasis cutaneous inflammation; apoptosis damaged DNA formation scars severe acne, respectively. observe comedones, pustules, papules cysts characteristic lesions, face thorax frequent location. incidence decreases between fourth fifth decades life, also, generally individuals lesions resolve spontaneously leaving cases.